樊青波;熊昆;陈琳;徐光亮;

• 1:西南科技大学四川省非金属复合与功能材料重点实验室

摘要(Abstract)：

采用液滴法,借助海藻酸钠(SA)与钙离子之间的交联反应,制备出具有核壳结构的还原氧化石墨烯/硅酸锌/硅酸钙(RGO/Zn2Si O4/Ca Si O3,RGO/ZS/CS)复合微球,并将盐酸万古霉素(Vancomycin Hydrochloride,VH)原位负载到复合微球中。XRD、FE-SEM、EDS、Raman和UV-Vis分光光度计,分别用于表征RGO/ZS/CS复合微球的物相组成、微观形貌、体外矿化行为及释药行为。研究结果显示,RGO/ZS/CS复合微球在人体模拟体液中浸泡28天,虽未矿化形成羟基磷灰石晶体,但其表面有胶状无定形磷酸钙沉积,表明RGO/ZS/CS复合微球仍具生物活性。VH在RGO/ZS/CS复合微球中的包封率为30.66%,RGO表面层与ZS中间层能有效地减缓VH的释放。总之,具有核壳结构的RGO/ZS/CS复合微球展现出良好的药物缓释性能。

关键词(KeyWords)： 硅酸钙;硅酸锌;还原氧化石墨烯;微球;盐酸万古霉素

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(51402247);; 西南科技大学研究生创新基金资助(16ycx020)

作者(Authors): 樊青波;熊昆;陈琳;徐光亮;

DOI: 10.16521/j.cnki.issn.1001-9642.2017.09.019

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